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  How cells dispose of their waste

Defective proteins that are not disposed of by the body can cause diseases such as Alzheimer's or Parkinson's. Scientists at the Max Planck Institute (MPI) of Biochemistry recently succeeded in revealing the structure of the cellular protein degradation machinery (26S proteasome) by combining different methods of structural biology. The results of collaboration with colleagues from the University of California, San Francisco and the Swiss Federal Institute of Technology Zurich (ETH Zürich) represent an important step forward in the investigation of the 26S proteasome. The findings have now been published in Proceedings of the National Academy of Sciences.

  No increase in brain tumours in the Nordic countries
The incidence of glioma - the most common form of brain tumour - is not increasing in the Nordic countries, contradicting the claim that mobile phone use is a cause of the disease. This according to a new study from Karolinska Institutet published in the scientific journal Epidemiology. The analyses presented by the researchers also show that the increased risks previously reported to be associated with mobile telephony in a few individual studies should have been observable in the general cancer statistics if mobile phone use had indeed been associated with a true risk increase.

 
S. Korea approves sales of new stem cell drug
Takeda Announces Strategic Measures to Achieve Efficiencies for Long-Term Growth

 

 




 
 
 
23.01.2012 Sartorius Stedim Biotech and Refine Technology Announce Cooperation  
Sartorius Stedim Biotech (SSB), a leading international pharma supplier, and Refine Technology (Refine), the developer and worldwide supplier to the biotech industry of the ATF™ System, a best-in-class cell retention device, will be collaborating on the development of a robust platform for high-density cell cultivation.  
 
   
 
23.01.2012 Active Biotech's Prostate Cancer Project TASQ in Phase I Combination Therapy Trial  
a Phase I Investigator sponsored clinical trial, led by Principal Investigator Dr.Andrew Armstrong at Duke University Hospital, US, has been announced for Active Biotech's (NASDAQ OMX Nordic: ACTI) prostate cancer project TASQ. The primary objective for the CATCH trial (Cabazitaxel (Jevtana) And Tasquinimod in Men with Castration-Resistant Heavily pre-treated ...  
 
   
 
23.01.2012 MediGene and EIP Eczacibasi Enter Agreement for the Commercialization of Veregen® in Turkey  
MediGene AG (Frankfurt: MDG, Prime Standard) (Frankfurt, Prime Standard, MDG) has signed an exclusive license and supply agreement with EIP Eczacibasi Ilac Pazarlama A.S. for the supply and commercialization of Veregen® ointment in Turkey. MediGene is entitled to successive payments, due upon the achievement of set regulatory and sales milestones, and will ...  
 
   
23.01.2012 MorphoSys Strengthens Patent Position on MOR202 Program  
MorphoSys AG (FSE: MOR; Prime Standard Segment; TecDAX) announced today that the US Patent and Trademark Office (USPTO) has granted a patent covering the Company's cancer compound MOR202. The new patent (US 8,088,896) covers MorphoSys's HuCAL antibody against CD38 as well as pharmaceutical compositions comprising the same, and has a scheduled expiry date in 2028, not including any potential regulatory extensions.  
 
   
 
20.02.2012 Cell Therapeutics, Inc. Expects That the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) May Issue an Opinion on the Marketing Authorization Application ("MAA") on Pixuvri™ in Mid-February  
Cell Therapeutics, Inc. ("CTI") (NASDAQ and MTA: CTIC) announced today that, following discussions with the European Medicines Agency's ("EMA") Committee for Medicinal Products for Human Use ("CHMP"), the CHMP may issue an opinion on CTI's Marketing Authorization Application ("MAA") for Pixuvri in mid-February. In the interim, CTI will continue to work ...  
 
   
 
18.01.2012 Sartorius Stedim Biotech and G-Con Manufacturing Announce Global Collaboration  
Sartorius Stedim Biotech and G-Con have agreed to a global collaboration to offer highly advanced and flexible production platforms for the biopharmaceutical manufacturing industry. The new product line will leverage G-Con Manufacturing’s novel modular, mobile clean-room “pods” and Sartorius Stedim Biotech’s well-established broad single-use and reusable product portfolio...  
 
   
 
18.01.2012 vivoPharm Accesses New Cancer Models for US Market  
vivoPharm Pty Ltd has entered into a partnership with Experimental Pharmacology & Oncology Berlin-Buch GmbH (EPO), one of Germanys -leading preclinical oncology testing company.  
 
   
 
18.01.2012 JSR Expands its Biomedical Business by Investing in BIA Separations' Unique Purification Technology  
JSR Corporation (Head Office: Minato-Ku, Tokyo, President: Mitsunobu Koshiba) and BIA Separations (Head Office: Villach, Managing Director and CEO: Aleš Štrancar) announced that they have entered a strategic partnership which includes a minor equity position by JSR on November 14th 2011.  
 
 
 
Advance Toward an Imaging Agent for Diagnosing Alzheimer's Disease
 
Scientists are reporting development and initial laboratory tests of an imaging agent that shows promise for detecting the tell-tale signs of Alzheimer's disease (AD) in the brain -- signs that now can't confirm a diagnosis until after patients have died. Their report appears in the journal ACS Medicinal Chemistry Letters.

 
A new way to stimulate the immune system and fight infection
 
These new data are an essential step towards understanding the operation of these key cells in the immune system, and they could provide a new therapeutic approach to fighting infection. They also suggest that the operation of NK cells must be precisely regulated to guarantee an optimum immune reaction.

 
Simpler Times: Did an Earlier Genetic Molecule Predate DNA and RNA?
 
In the chemistry of the living world, a pair of nucleic acids -- DNA and RNA -- reign supreme. As carrier molecules of the genetic code, they provide all organisms with a mechanism for faithfully reproducing themselves as well as generating the myriad proteins vital to living systems. Yet according to John Chaput, a researcher at the Center for Evolutionary Medicine and Informatics, at Arizona State University's Biodesign Institute®, it may not always have been so.

 
Essential protein for the formation of new blood vessels identified
 
Angiogenic sprouting, the process by which new blood vessels grow from existing vessels, is a double-edged sword. It enables the cardiovascular system to develop in the embryo, and is vital for tissue regeneration in adults. But it also supplies growing tumors with nutrients and oxygen.

 
Anti-malaria drug synthesised with the help of oxygen and light
 
The most effective anti-malaria drug can now be produced inexpensively and in large quantities. This means that it will be possible to provide medication for the 225 million malaria patients in developing countries at an affordable price. Researchers at the Max Planck Institute of Colloids and Interfaces in ...

 
Rare Chinese white dolphin gets DNA bank
 

There are about 2,500 Chinese white dolphins in the Pearl River Delta region, the body of water between Macau and Hong Kong, with the majority of the mammals in Chinese waters and the rest in Hong Kong.

But experts say their number has dropped significantly in the past few years due to overfishing, an increase in maritime traffic, water pollution, habitat loss and coastal development.

 
Brain Glia Cells Increase Their DNA Content to Preserve Vital Blood-Brain Barrier
 

The blood-brain barrier is essential for maintaining the brain's stable environment -- preventing entry of harmful viruses and bacteria and isolating the brain's specific hormonal and neurotransmitter activity from that in the rest of the body.

 
Scientists characterize protein essential to survival of malaria parasite
 

A biology lab at Washington University has just cracked the structure and function of a protein that plays a key role in the life of a parasite that killed 655,000 people in 2010. The protein is an enzyme that Plasmodium falciparum, the protozoan that causes the most lethal form of malaria, uses to make cell membrane. The protozoan cannot survive without this enzyme, but even though the enzyme has many lookalikes in other organisms, people do not make it. Together these characteristics make the enzyme an ideal target for new antimalarial drugs.

 
Backing out of the nanotunnel
 

In the world of biomolecules such as proteins and the hereditary nucleic acids DNA and RNA, three-dimensional structure determines function. Analysis of the passage of such molecules through nanopores offers a relatively new, but highly promising, technique for obtaining information about their spatial conformations.

 
How poor maternal diet can increase risk of diabetes -- new mechanism discovered
 

Researchers funded by the Biotechnology and Biological Sciences Research Council have shown one way in which poor nutrition in the womb can put a person at greater risk of developing type 2 diabetes and other age-related diseases in later life. This finding could lead to new ways of identifying people who are at a higher risk of developing these diseases and might open up targets for treatment.

 
A firmer understanding of muscle fibrosis
 

Researchers describe how increased production of a microRNA promotes progressive muscle deterioration in a mouse model of Duchenne muscular dystrophy (DMD), according to a study published online on January 2 in the Journal of Cell Biology (www.jcb.org).

   
 
   
 
 
Delivering the new community pharmacy contract: Essential cross sector communication webinar
  26th January 2012
The aim of the webinar is to highlight the essential cross sector communications required between primary and secondary care to support the new medicine service and targeted MURs
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 Bio-Images and Medimetrics partner to deliver the next generation of smart pill technology
Bio-Images Research and Medimetrics Personalized Drug Delivery have today announced a partnership to introduce the IntelliCap to the global pharmaceutical industry as a clinical research tool. The announcement was made at the annual meeting of the American Association of Pharmaceutical Scientists, being held in Washington DC, USA, between 23 and 27 October 2011.
 
   
 
New sweat test allows  easier diagnosis of cystic fibrosis

Medical technology company Tecil has obtained EC approval for their chloride sweat test, , which is used to diagnose cystic fibrosis. This product is innovative due to the fact that, "compared to the high number of different steps  in using the classical method, it is able to safely and quickly determine the chloride concentration in micro-samples of sweat  directly on the patient’s skin," explains General Manager Rosa Passarell.
 
   
 
  Phenom-World launches the Temperature Controlled Sample Holder and improved Fibermetric a...
With these two launches Phenom-World BV further extends the usability of the Phenom G2 desktop SEM’s. Giving the opportunity to image vacuum-sensitive and vulnerable samples without damaging the sample structure by using the Temperature Controlled Sample Holder. Secondly the new version of Fibermetric is able to take the analysis of fibers and filter to an even higher level.   
 
   
 
Liquid Liquid Extraction of Vitamin D using VERSA™ LLE Workstation
  Vitamin D deficiency is associated with many pathological conditions including diabetes, osteoarthritis, and many forms of cancer. Several methods are available to assess vitamin D sufficiency through measurement of serum 25-hydroxy vitamin D [25(OH)D]. Antibody (ELISA) or other protein-binding assays are available, but may not accurately report total vitamin D values. Moreover, manual sample preparation methods for assays such as LC-MS/MS or HPLC are very cumbersome.
 
7th Annual International Conference on Predictive Human Toxicity and ADME/Tox Studies
26th-27th January 2012
 
Cool Chain Logistics Europe 2012
30th January – 1st February 2012
 
  2nd Annual Pharma R&D World Asia Congress 2012
13 Feb 2012 – 14 Feb 2012
 
  Clinical Trials & Outsourcing Asia Congress 2012
13 Feb 2012 – 14 Feb 2012
 
 
  1st Annual CNS Biomarkers Congress 2012
21 Feb 2012 – 22 Feb 2012
 
 
 
Medical Director Clinical Development-Diabetes and Cardiovascular (UK)  
   
 
Regulatory Manager  
   
 
Junior Clinical Project Manager  
   
 
Assistant Clinical Project Manager  
   
 
Senior Scientist in Life Science
Scientific Officer
Research Scientist with over 10 years of interdisciplinary experience and expertise in molecular biology, virology, immunology and biochemistry
Post doctoral associate at Rockefeller University
Business Development Professional looking for employment in Belgium
Expertise in Plant Technologies and Conservation
Section Head
Business Development Professional
Highly talented Protein Biochemist
Ph.D. ( medical genetics )
Phd student in Nano-science center
A scientist with Six years of experience in the pharmaceutical CRO business
Masters of Science in Biology with more then 10 years Research Experience
PhD student in Molecular Biology/Microbiology/Biochemistry
Assistant Professor and Director of Research Department of Ophthalmology
Validation Engineer
 


 

 

 

                                       

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